SRI-011381 (hydrochloride)
SRI-011381 (hydrochloride)
CAS: 2070014-88-7
Molecular Formula: C20H32ClN3O
SRI-011381 (hydrochloride) - Names and Identifiers
| Name | SRI-011381 (hydrochloride) |
| Synonyms | SRI-011381 (hydrochloride) |
| CAS | 2070014-88-7 |
SRI-011381 (hydrochloride) - Physico-chemical Properties
| Molecular Formula | C20H32ClN3O |
| Molar Mass | 365.95 |
| In vitro study | SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages. SRI-011381 hydrochloride (10 μM) eliminates Saikosaponin A (SSA, 30 μM)-induced protective effects on fibroblasts. |
SRI-011381 (hydrochloride) - References
| biological activity | SRI-011381 hydrochloride is an activator of TGF-beta signaling pathway with oral biological activity, which has neuroprotective effect. |
| Target | TGF-beta |
| Animal Model: | FBV mice |
| Dosage: | 10 mg/kg, 30 mg/kg, 75 mg/kg |
| Administration: | Oral administration; 14 days |
| Result: | Resulted in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin |
Last Update：2024-04-09 21:11:58
